Key result
Among 30 patients with von Willebrand's disease, all 6 with severe disease lacked detectable platelet VIIIR: Ag, while 19 with mild disease had detectable but often reduced levels.
Population
30 patients with various forms of von Willebrand's disease (6 severe type I, 19 mild, 5 genetic variants)
Design
Cross-sectional
Authors
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May aid severity stratification in von Willebrand disease; leaves open added diagnostic value over plasma assays.
Observational (n=30)
The platelet content of VIIIR: Ag correlates with plasma levels and disease severity in patients with von Willebrand's disease.
Holmbeg et al. (1979) conducted an observational in von Willebrand's disease (n=30). von Willebrand's disease vs. Normal controls was evaluated on VIIIR: Ag levels in platelets. Among 30 patients with von Willebrand's disease, all 6 with severe disease lacked detectable platelet VIIIR: Ag, while 19 with mild disease had detectable but often reduced levels.
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