In vivo endotoxemia triggers functional inhibition of the Ang-1/Tie-2 receptor pathway by reducing Ang-1 and Tie-2 expression and inducing Ang-2 levels, which may contribute to enhanced vascular leakage in sepsis.
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May link endotoxemia to vascular leak via Ang/Tie-2 inhibition; leaves open whether pathway modulation improves sepsis outcomes.
Mofarrahi et al. (2008) studied this question.
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