Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 30, 2004The FASEB Journal

Biological characterization of angiopoietin‐3 and angiopoietin‐4

View Full Paper
Ask AI
Bookmark
Share

Population

Primary cultured human umbilical vein endothelial cells, primary cultured mouse lung microvascular…

Comparison

Recombinant Ang3 and Ang4 proteins vs Ang3 compared to Ang4

Design

Preclinical

Authors

HLHyuek Jong LeeCCChung‐Hyun ChoSeoul National UniversitySHSu-Jeong Hwang

Discussion

Loading...

Member takes

Implication

Species-specific Ang3/Ang4 Tie2 effects leave open human translation of mouse angiogenesis models; cautions against assuming cross-species agonist equivalence.

Structured PICO

P
Population
Primary cultured human umbilical vein endothelial cells (HUVECs), primary cultured mouse lung microvascular endothelial cells, and mice in vivo
I
Intervention
Recombinant Ang3 and Ang4 proteins (400 ng/mL in vitro, 30 microg intravenously in vivo)
C
Comparator
Ang3 compared to Ang4
O
Outcome
Tie2 and Akt phosphorylation, cell survival, migration, and corneal angiogenesissurrogate

Ang3 and Ang4 are both agonists of the Tie2 receptor, but mouse Ang3 exhibits species-specific activity on mouse endothelial cells.

Cite This Study

Lee et al. (2004) studied this question.

synapsesocial.com/papers/6a7120e7f44fa9f079dee63bhttps://doi.org/10.1096/fj.03-1466com
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiopoietins 3 and 4: Diverging gene counterparts in mice and humans1999 · 472 citations
  2. 2The angiopoietin–tie2 system in coronary artery endothelium prevents oxidized low-density lipoprotein-induced apoptosis2001 · 36 citations
  3. 3Angiopoietin-1 Inhibits Irradiation- and Mannitol-Induced Apoptosis in Endothelial Cells2000 · 93 citations
  4. 4Differential expression of Tie-2 receptors and angiopoietins in response to in vivo hypoxia in rats2001 · 69 citations
  5. 5Molecular Cloning, Expression, and Characterization of Angiopoietin-related Protein1999 · 215 citations