December 1, 2006Microbiology and ImmunologyOpen Access

Prolonged Viral RNA Detection in Blood and Lymphoid Tissues from Coxsackievirus B4 E2 Orally‐Inoculated Swiss Mice

View Full Paper

Ask AI

Bookmark

Population

Swiss Albino outbred mice

Design

Preclinical

Follow-up

8 hours to 150 days

Authors

HJHela JaïdaneUniversity of Monastir JGJawhar GharbiKing Faisal University PLPierre‐Emmanuel LobertUniversité de Lille

Discussion

Member takes

Implication

Hypothesis-generating for persistent enteroviral infection in humans; leaves open clinical relevance pending translational studies.

Structured PICO

Population

Swiss Albino outbred mice

Intervention

Oral inoculation with coxsackievirus B4 E2 strain (CVB4 E2)

Outcome

Detection of viral RNA in various organs (pancreas, heart, small intestine, spleen, thymus, and blood) using RT-PCR and semi-nested-RT-PCR methodssurrogate

Oral inoculation of outbred mice with coxsackievirus B4 E2 leads to systemic infection and prolonged viral RNA persistence in lymphoid tissues and blood.

Cite This Study

Jaïdane et al. (2006) studied this question.

synapsesocial.com/papers/6a8a4ecdabe412682d9321dd https://doi.org/10.1111/j.1348-0421.2006.tb03874.x

View Full Paper

Ask AI

Bookmark

Prolonged Viral RNA Detection in Blood and Lymphoid Tissues from Coxsackievirus B4 E2 Orally‐Inoculated Swiss Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Prolonged Viral RNA Detection in Blood and Lymphoid Tissues from Coxsackievirus B4 E2 Orally‐Inoculated Swiss Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider