May 1, 1997Journal of Cardiovascular Electrophysiology

Sawtooth First Phase Biphasic Defibrillation Waveform

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Why the study?

Does a sawtooth biphasic defibrillation waveform improve defibrillation efficacy compared to conventional waveforms in a pig model?

Population

13 anesthetized pig models

Comparison

Sawtooth biphasic defibrillation waveform… vs Two clinical waveforms: a 135-microF capacitance…

Design

Preclinical

Authors

YYYoshio YamanouchiTohoku Institute of Technology JBJames E. BrewerUniversity of Southern California KMKent A. MowreySt. Jude Medical Center

Discussion

Member takes

Implication

Sawtooth waveform lowers defibrillation energy in pigs; leaves open translation to clinical defibrillators.

Structured PICO

Does a sawtooth biphasic defibrillation waveform improve defibrillation efficacy compared to conventional waveforms in a pig model?

Population

13 anesthetized pig models

Intervention

Sawtooth biphasic defibrillation waveform constructed using "parallel-series" switching of capacitances (each 30 microF) during the first phase

Comparator

Two clinical waveforms: a 135-microF capacitance (control-1) and a 90-microF capacitance (control-2) waveform

Outcome

Defibrillation threshold (DFT) parameters (stored energy and average current of the first phase)surrogate

A sawtooth biphasic waveform utilizing parallel-series switching of smaller capacitors improves defibrillation efficacy by lowering the defibrillation threshold energy and increasing the first-phase average current in a pig model.

Cite This Study

Yamanouchi et al. (1997) studied this question.

synapsesocial.com/papers/6a8a4ecf755d28965dfd6463 https://doi.org/10.1111/j.1540-8167.1997.tb00820.x

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