October 1, 1996Circulation

Large Change in Voltage at Phase Reversal Improves Biphasic Defibrillation Thresholds

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Why the study?

Does a biphasic waveform with large voltage changes at phase reversal reduce defibrillation threshold energy in a pig model?

Population

8 anesthetized pigs

Comparison

Experimental biphasic waveforms with large… vs Control biphasic waveforms where phase 1…

Design

Preclinical

Authors

YYYoshio YamanouchiTohoku Institute of Technology KMKent A. MowreySt. Jude Medical Center GNGeorge R. NadzamCleveland Clinic

Discussion

Member takes

Implication

Potential for smaller ICD capacitors; hypothesis-generating in pigs, human translation studies required.

Structured PICO

Does a biphasic waveform with large voltage changes at phase reversal reduce defibrillation threshold energy in a pig model?

Population

8 anesthetized pigs

Intervention

Experimental biphasic waveforms with large voltage changes at phase reversal (phase 2 leading-edge voltage twice the phase 1 trailing-edge voltage, achieved by switching two capacitors from parallel to series mode), using 60/15 microF and 90/22.5 microF capacitors

Comparator

Control biphasic waveforms where phase 1 trailing-edge voltage equaled phase 2 leading-edge voltage, using 135/135 microF (clinical) or 90/90 microF (investigational) capacitors

Outcome

Stored energy at the defibrillation threshold (joules)surrogate

Biphasic waveforms with large voltage changes at phase reversal significantly reduce defibrillation threshold energy requirements in a pig model, potentially allowing for smaller device capacitors.

Cite This Study

Yamanouchi et al. (1996) studied this question.

synapsesocial.com/papers/6a8a4ecf755d28965dfd6464 https://doi.org/10.1161/01.cir.94.7.1768

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Large Change in Voltage at Phase Reversal Improves Biphasic Defibrillation Thresholds

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Large Change in Voltage at Phase Reversal Improves Biphasic Defibrillation Thresholds

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider