Why the study?
Does respiratory viral infection aggravate airway damage in rat lung allografts with chronic rejection?
Population
Rats divided into 3 groups: nontransplanted LEW lungs, LEW-to-LEW syngeneic lung transplants, and BN-to-LEW…
Comparison
Intratracheal infection with Sendai virus 6… vs Noninfected rats of the same groups.
Design
Preclinical
Follow-up
Up to 56 days after infection
Authors
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May warrant antiviral vigilance in lung allograft recipients; leaves open translation from rat models to clinical chronic rejection.
Does respiratory viral infection aggravate airway damage in rat lung allografts with chronic rejection?
Respiratory viral infections synergistically aggravate airway damage and promote features of bronchiolitis obliterans in rat lung allografts undergoing chronic rejection.
Winter et al. (1994) studied this question.
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