Why the study?
Does allogeneic lung transplantation impair the local and systemic antibody response against respiratory viral infection in a rat model?
Population
Rats divided into 3 groups: BN-to-LEW allogeneic lung transplants, LEW-to-LEW syngeneic lung transplants…
Comparison
Intratracheal viral infection with Sendai virus… vs Syngeneic lung transplants and nontransplanted…
Design
Preclinical
Follow-up
56 days after infection
Authors
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Allogeneic rat lung allografts impair local and systemic antiviral antibody responses with prolonged viral persistence; leaves open relevance to infection risk in human recipients.
Does allogeneic lung transplantation impair the local and systemic antibody response against respiratory viral infection in a rat model?
In a rat model, lung allografts demonstrate inadequate local and systemic antibody responses to respiratory viral infection, leading to prolonged viral presence and potentially explaining the high susceptibility of lung transplant recipients to viral infections.
Winter et al. (1995) studied this question.
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