The predominance of CD8+ T cells in bronchiolitis obliterans lesions supports the hypothesis that chronic rejection is a mechanism for its development after heart-lung transplantation.
Supports CD8-driven chronic rejection hypothesis in post-transplant bronchiolitis obliterans; hypothesis-generating case report requires prospective validation.
The long-term success of heart-lung transplantation is limited by the development of bronchiolitis obliterans, possibly as a form of chronic lung allograft rejection. In the present study, we have characterized by immunohistochemical staining the lymphocytes infiltrating the lesions of bronchiolitis obliterans in one patient following heart-lung transplantation. The finding that the preponderant cells expressed the CD8 (putative cytotoxic/suppressor) marker lends support to the notion that chronic rejection is at least one mechanism for the development of bronchiolotis obliterans following heart-lung transplantation.
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HOLLAND et al. (1990) studied this question.
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