Why the study?
Does ambulatory blood pressure monitoring better detect differences in antihypertensive therapy response compared to office blood pressure readings in patients with essential hypertension?
Population
37 patients with essential hypertension (7 in clonidine study, 30 in timolol vs methyldopa study)
Comparison
Timolol 10-20 mg/d for 6 weeks added to baseline… vs Methyldopa 250-500 mg/d for 6 weeks added to…
Design
RCT, double-blind fashion
Follow-up
4 to 6 weeks
Authors
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ABPM may better capture antihypertensive response differences than office readings; extends its role in comparative hypertension RCTs.
Does ambulatory blood pressure monitoring better detect differences in antihypertensive therapy response compared to office blood pressure readings in patients with essential hypertension?
Ambulatory blood pressure monitoring can detect significant differences in antihypertensive drug efficacy that are missed by standard office blood pressure readings.
Waeber et al. (1985) studied this question.
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