Why the study?
Does felodipine administration alter beta-adrenergic receptor density and reflex tachycardia in patients with essential hypertension?
Does felodipine administration alter beta-adrenergic receptor density and reflex tachycardia in patients with essential hypertension?
Repeated felodipine administration in essential hypertension does not cause beta-adrenoceptor down-regulation, and reflex tachycardia is reset to lower blood pressure levels rather than abolished.
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Supports lack of beta-adrenoceptor down-regulation with repeated felodipine; leaves open clinical impact of tachycardia reset in hypertension.
Savonitto et al. (1991) studied this question.
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