Why the study?
Are there sex-related differences in the pharmacokinetics and heart rate response to atropine in elderly patients?
Are there sex-related differences in the pharmacokinetics and heart rate response to atropine in elderly patients?
The pharmacokinetics and heart rate response to a single intravenous dose of atropine in elderly patients do not differ by sex.
Supports equivalent atropine dosing by sex in elderly patients; leaves open confirmation in larger or younger cohorts.
Sex-related changes in the pharmacokinetics and pharmacodynamics (heart rate) of atropine were studied in female (n = 9) and male (n = 9) elderly patients after a single 0.02 mg/kg i.v. injection of the drug at the beginning of a combination anaesthesia. No significant differences were found between the sexes, which indicates that there are no sex-related alterations in the response to this anticholinergic agent.
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Kanto et al. (1987) studied this question.
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