Why the study?
Does low-dose aspirin therapy cause fetal malformation in pregnant patients with systemic lupus erythematosus and elevated cardiolipin antibodies?
Does low-dose aspirin therapy cause fetal malformation in pregnant patients with systemic lupus erythematosus and elevated cardiolipin antibodies?
This case report discusses a potential association between low-dose aspirin therapy during pregnancy and fetal skeletal deformities in a patient with systemic lupus erythematosus and anticardiolipin syndrome.
Case report of hemivertebrae after low-dose aspirin in lupus pregnancy; hypothesis-generating and should not change practice.
A patient with systemic lupus erythematosus and elevated cardiolipin antibody levels was given low-dose aspirin therapy prior to and throughout her third pregnancy to minimize the risk of miscarriage. She delivered a boy at 38 weeks with the skeletal deformity of two thoracic hemivertebrae. The putative role of aspirin causing this birth defect is discussed.
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Chakravarty et al. (1993) studied this question.
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