March 22, 2017PLoS ONEOpen Access

C-reactive protein and N-terminal prohormone brain natriuretic peptide as biomarkers in acute exacerbations of COPD leading to hospitalizations

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Why the study?

Does the combination of CRP and NT-proBNP accurately discriminate acute exacerbations of COPD requiring hospitalization from stable COPD?

Population

578 patients, comprising 468 hospitalized with a primary diagnosis of acute exacerbation of chronic…

Comparison

Measurement of serum C-reactive protein and… vs Stable COPD patients (clinical stability).

Design

Cohort

Authors

YCYu-wei Roy Chen VCVirginia ChenPrevention of Organ Failure ZHZsuzsanna HollanderPrevention of Organ Failure

Discussion

Member takes

Implication

The combination of CRP and NT-proBNP biomarkers can accurately discriminate acute exacerbations of COPD requiring hospitalization from stable disease.

Structured PICO

Does the combination of CRP and NT-proBNP accurately discriminate acute exacerbations of COPD requiring hospitalization from stable COPD?

Population

578 patients, comprising 468 hospitalized with a primary diagnosis of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and 110 stable COPD patients serving as controls.

Intervention

Measurement of serum C-reactive protein (CRP) and whole blood N-terminal prohormone brain natriuretic peptide (NT-proBNP) concentrations.

Comparator

Stable COPD patients (clinical stability).

Outcome

Discriminatory power (Area Under the Curve, AUC) to separate AECOPD requiring hospitalization from convalescent or stable COPD patients.surrogate

The combination of CRP and NT-proBNP biomarkers can accurately discriminate acute exacerbations of COPD requiring hospitalization from stable disease.

Cite This Study

Chen et al. (2017) studied this question.

synapsesocial.com/papers/6a8a598006e1858e55de85f8 https://doi.org/10.1371/journal.pone.0174063

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Implication

The combination of CRP and NT-proBNP biomarkers can accurately discriminate acute exacerbations of COPD requiring hospitalization from stable disease.

C-reactive protein and N-terminal prohormone brain natriuretic peptide as biomarkers in acute exacerbations of COPD leading to hospitalizations

Discussion

Member takes

Implication

Structured PICO

Cite This Study

C-reactive protein and N-terminal prohormone brain natriuretic peptide as biomarkers in acute exacerbations of COPD leading to hospitalizations

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider