October 15, 2004Journal of Biological ChemistryOpen Access

The α1 Isoform of Na,K-ATPase Regulates Cardiac Contractility and Functionally Interacts and Co-localizes with the Na/Ca Exchanger in Heart

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Structured PICO

Population

Genetically engineered knock-in mice expressing a ouabain-sensitive alpha 1 isoform and a ouabain-resistant alpha 2 isoform of the Na,K-ATPase, and isolated heart preparations

Intervention

Ouabain administration (with or without KB-R7943 pretreatment)

Outcome

Cardiac contractility (inotropy)surrogate

The alpha 1 isoform of Na,K-ATPase regulates cardiac contractility and functionally interacts with the Na/Ca exchanger in the heart.

Discussion

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Implication

Warrants caution before clinical translation of ouabain-like inotropes; leaves open therapeutic targeting of α1 Na,K-ATPase-NCX interaction.

Cite This Study

Dostanic et al. (2004) studied this question.

synapsesocial.com/papers/6a8a5def06e1858e55de87e6 https://doi.org/10.1074/jbc.m410737200

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Implication

Warrants caution before clinical translation of ouabain-like inotropes; leaves open therapeutic targeting of α1 Na,K-ATPase-NCX interaction.