Key result
In a rat model of congestive heart failure, I NKA,alpha2 density was reduced by 78% and protein expression by 74%, leading to attenuated control of NCX activity.
Effect estimate: 78% reduction
Downregulation of the NKA alpha2-isoform in heart failure impairs the control of Na+/Ca2+ exchange, contributing to defective Ca2+ extrusion and altered cardiomyocyte contraction.
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Alpha2-NKA downregulation may impair Ca2+ extrusion in HF; leaves open isoform-specific targeting as a therapeutic strategy.
Swift et al. (2008) studied Congestive heart failure. Congestive heart failure vs. Sham-operated rats was evaluated on I NKA,alpha2 density (78% reduction). In a rat model of congestive heart failure, I NKA,alpha2 density was reduced by 78% and protein expression by 74%, leading to attenuated control of NCX activity.
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