Why the study?
Does congestive heart failure or chronic norepinephrine infusion reduce specific isoforms of the myocardial Na,K-ATPase alpha-subunit in dogs?
Does congestive heart failure or chronic norepinephrine infusion reduce specific isoforms of the myocardial Na,K-ATPase alpha-subunit in dogs?
The reduction of myocardial Na,K-ATPase in congestive heart failure is specific to the alpha 3 isoform and appears to be mediated by excess sympathetic stimulation.
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Does not yet change practice in heart failure; extends prior observations by showing alpha 3-specific Na,K-ATPase reduction mediated by norepinephrine in dogs.
Kim et al. (1994) studied this question.
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