Why the study?
Does intrarenal ouabain affect sodium excretion, urine volume, and plasma renin activity in normal dogs and dogs with pacing-induced congestive heart failure?
Does intrarenal ouabain affect sodium excretion, urine volume, and plasma renin activity in normal dogs and dogs with pacing-induced congestive heart failure?
Ouabain has direct renal diuretic and natriuretic actions independent of its inotropic effects, and suppresses renin activation in heart failure.
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Highlights potential direct renal natriuretic effects of ouabain beyond inotropy in experimental CHF; leaves open human translation.
Lloyd et al. (1992) studied this question.
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