Key result
Elevated myocardial norepinephrine downregulates Na+/K+-ATPase alpha 3-subunit protein post-transcriptionally in the failing heart.
Elevated myocardial interstitial norepinephrine contributes to post-transcriptional down-regulation of Na+,K+-ATPase alpha 3-subunit in failing myocardium, while additional factors drive transcriptional down-regulation.
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Hypothesis-generating in animal HF models; leaves open norepinephrine effects on Na+,K+-ATPase in patients.
Lai et al. (1996) studied Congestive heart failure. Pacing-induced congestive heart failure and chronic norepinephrine infusion was evaluated on Myocardial Na+,K(+)-ATPase alpha 3-subunit protein and gene expression. Elevated myocardial interstitial norepinephrine levels contribute to the down-regulation of the Na+,K(+)-ATPase alpha 3-subunit protein via a post-transcriptional mechanism in the failing myocardium.
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