Population
20 rats (8 with myocardial infarction-induced chronic heart failure, 12 sham-operated controls)
Comparison
Myocardial infarction induction to cause chronic… vs Sham operation
Design
Preclinical
Follow-up
approximately 180 days after surgery
Authors
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May limit exercise capacity in chronic HF; leaves open human translation and therapeutic targeting of skeletal muscle Na+ pumps.
Chronic heart failure in rats is associated with a significant reduction in skeletal muscle Na+ pump number, which may contribute to decreased exercise capacity.
Pickar et al. (1997) studied this question.
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