Population
41 rats. Among MI rats, 18 had moderate LV dysfunction and 5 had severe LV dysfunction.
Comparison
Myocardial infarction to induce chronic heart… vs Sham-operated control rats
Design
Preclinical
Follow-up
8-10 weeks postsurgery
Authors
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Hypothesis-generating for Na-K pump downregulation contributing to exercise intolerance in HF; human validation required before clinical relevance.
Downregulation of Na(+)-K(+) pumps with high affinity for ouabain in oxidative skeletal muscle may contribute to exercise intolerance in severe chronic heart failure.
Musch et al. (2002) studied this question.
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