Key result
Failing human hearts demonstrated increased sensitivity to ouabain, associated with a 42% reduction (95% CI 26-56%) in Na/K-ATPase concentration compared to non-failing hearts.
Population
Isolated trabeculae and tissue samples from terminally failing explanted human hearts and non-failing human…
Comparison
Ouabain exposure (in vitro) vs Tissue from non-failing human hearts
Design
Preclinical
Authors
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Supports altered digitalis sensitivity in HF via Na/K-ATPase loss; leaves open clinical translation and dosing implications.
Effect estimate: 42% reduction (95% CI 26-56)
Absolute Event Rate: 293% vs 507%
p-value: p=<0.001
Failing human hearts exhibit increased sensitivity to ouabain, likely due to a significant reduction in Na/K-ATPase concentration rather than changes in catalytic properties or isoform composition.
Shamraj et al. (1993) studied Heart failure (n=18). Heart failure vs. Non-failing hearts was evaluated on [3H]Ouabain binding (pmol/g wet weight) (42% reduction, 95% CI 26-56, p=<0.001). Failing human hearts demonstrated increased sensitivity to ouabain, associated with a 42% reduction (95% CI 26-56%) in Na/K-ATPase concentration compared to non-failing hearts.
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