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June 16, 2022International Journal of Molecular SciencesOpen Access

Early Postoperative Immunothrombosis of Bioprosthetic Mitral Valve and Left Atrium: A Case Report

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Population

A 72-year-old female patient with mixed rheumatic mitral valve disease and persistent atrial fibrillation

Design

Case report

Authors

AKA. E. KostyuninТГТ. В. ГлушковаАСА. Н. Стасев

Discussion

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Overview

Early postoperative thrombosis risks persist after bioprosthetic MVR in rheumatic disease with AF; hypothesis-generating for optimized perioperative anticoagulation strategies.

Structured PICO

P
Population
72-year-old female with mixed rheumatic mitral valve disease, persistent atrial fibrillation, and inherited thrombophilia
I
Intervention
Mitral valve replacement (bioprosthetic) followed by repeated valve replacement and left atrial thrombectomy
O
Outcome
Recurrent prosthetic valve and left atrial thrombosis leading to deathhard clinical

This case highlights the potential hazard and mechanisms of early postoperative immunothrombosis, characterized by NET release and anticoagulant resistance, following bioprosthetic mitral valve replacement.

Cite This Study

Kostyunin et al. (2022) studied this question.

synapsesocial.com/papers/6a8a5fd6e0083a7c2c436e4chttps://doi.org/10.3390/ijms23126736
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Bioprosthetic Valve Thrombosis2018 · 41 citations
  2. 2Histopathological evaluation of thrombus in patients presenting with stent thrombosis. A multicenter European study: a report of the prevention of late stent thrombosis by an interdisciplinary global European effort consortium2015 · 196 citations
  3. 3Bioprosthetic Valve Thrombosis Versus Structural Failure2015 · 301 citations
  4. 4Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo2012 · 1,840 citations
  5. 5Mechanical Stability and Fibrinolytic Resistance of Clots Containing Fibrin, DNA, and Histones2013 · 295 citations