Key result
Therapeutic anticoagulation resolved prosthetic valve thrombosis in a patient with discrepant INR levels due to antiphospholipid antibody cross-reactivity.
Case Report (n=1)
Highlights the potential for antiphospholipid antibody cross-reactivity to cause discrepant INR levels and subsequent mechanical valve thrombosis, which can be resolved with therapeutic anticoagulation.
Alerts clinicians to antiphospholipid interference with point-of-care INR in mechanical valve patients; leaves open whether alternative assays improve thrombosis detection.
A 54-year-old woman with a mechanical mitral valve replacement presented with recurrent admissions for pneumonia and pulmonary edema. Multimodality imaging revealed mobile masses on the prosthesis and discrepant point of care and inpatient international normalized ratio levels owing to antiphospholipid antibody cross-reactivity on the outpatient assay. The prosthetic valve thromboses resolved with therapeutic anticoagulation. (Level of Difficulty: Beginner.)
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Chitturi et al. (2020) conducted a case report in Mechanical mitral valve thrombosis (n=1). Therapeutic anticoagulation was evaluated on Resolution of prosthetic valve thrombosis. Therapeutic anticoagulation resolved prosthetic valve thrombosis in a patient with discrepant INR levels due to antiphospholipid antibody cross-reactivity.