September 24, 2002Circulation
Tissue Engineering of Functional Trileaflet Heart Valves From Human Marrow Stromal Cells
Population
Human marrow stromal cells (MSC)
Comparison
Tissue engineering of trileaflet heart valves… vs Human native-heart-valve tissue
Design
Preclinical
Authors
Discussion
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Member takes
Overview
Supports MSC-engineered valves in animal models; leaves open human translation pending prospective trials.
Structured PICO
P
Population
Human marrow stromal cells (MSC)
I
Intervention
Tissue engineering of trileaflet heart valves using rapidly bioabsorbable polymers seeded with MSC and grown in vitro in a pulsatile-flow-bioreactor
C
Comparator
Human native-heart-valve tissue (for mechanical properties)
O
Outcome
Morphological features, extracellular matrix formation, and mechanical properties of the tissue-engineered heart valvessurrogate
Human marrow stromal cells can be used to engineer functional trileaflet heart valves with morphological and mechanical properties comparable to native tissue.
Cite This Study
Hoerstrup et al. (2002) studied this question.