Population
Fibrin-based tissue-engineered heart valve leaflets and ovine pulmonary valve leaflets
Comparison
Decellularization using 1% sodium dodecyl… vs Decellularized native leaflets
Design
Preclinical
Follow-up
1 and 3 weeks
Authors
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Preclinical data support further optimization of engineered leaflets; leaves open translation to pediatric valve trials.
Decellularized tissue-engineered heart valve leaflets maintain native-like mechanical properties while offering superior recellularization potential compared to native leaflets, presenting a promising approach for pediatric valve replacement.
Syedain et al. (2012) studied this question.
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