January 20, 2015Translational PsychiatryOpen Access

C-reactive protein gene variants: independent association with late-life depression and circulating protein levels

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Why the study?

Are CRP gene variants associated with late-life depression and circulating CRP levels in people aged 65 and older?

Population

990 people aged at least 65 years from the ESPRIT study

Design

Cohort

Authors

Discussion

Suggests CRP variants as potential sex-specific markers for late-life depression; hypothesis-generating and should not yet change practice.

Are CRP gene variants associated with late-life depression and circulating CRP levels in people aged 65 and older?

Population

990 people aged at least 65 years from the ESPRIT study

Intervention

CRP gene variants (five single-nucleotide polymorphisms spanning the CRP gene)

Outcome

Clinical level of depression (DEP) and circulating levels of high-sensitivity CRP

Variants of the CRP gene influence circulating CRP levels and appear as independent susceptibility factors for late-life depression in women.

Carrière et al. (2015) studied this question.

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Suggests CRP variants as potential sex-specific markers for late-life depression; hypothesis-generating and should not yet change practice.