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January 1, 2014Cellular Physiology and BiochemistryOpen Access

CYP2J2 and EETs Protect against Oxidative Stress and Apoptosisin Vivoandin VitroFollowing Lung Ischemia/Reperfusion

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Why the study?

Does CYP2J2 overexpression or exogenous EETs reduce oxidative stress and apoptosis in lung ischemia/reperfusion injury models?

Population

Rat model of lung ischemia/reperfusion injury and human pulmonary artery endothelial cells-based…

Design

Preclinical

Follow-up

2 hours of reperfusion (in vivo)

Authors

WCWenshu ChenGZGuanying ZhengSYShijiang Yang

Discussion

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Overview

May protect against experimental lung I/R injury; extends preclinical EET data but leaves open human translation.

Structured PICO

Does CYP2J2 overexpression or exogenous EETs reduce oxidative stress and apoptosis in lung ischemia/reperfusion injury models?

P
Population
Rat model of lung ischemia/reperfusion injury (clamping left lung hilum for 1 hour, reperfusion for 2 hours) and human pulmonary artery endothelial cells (HPAECs)-based anoxia/reoxygenation model
I
Intervention
CYP2J2 gene stable transfection via pcDNA3.1-CYP2J2 plasmid delivery (in vivo) and exogenous EETs or CYP2J2 overexpression (in vitro)
O
Outcome
Levels of oxidative stress and cell apoptosis in lung tissuessurrogate

CYP2J2 overexpression and exogenous EETs protect against oxidative stress and apoptosis in lung ischemia/reperfusion injury, suggesting a potential therapeutic strategy.

Cite This Study

Chen et al. (2014) studied this question.

synapsesocial.com/papers/6a8a6d57331f3ed9ab2e57f7https://doi.org/10.1159/000362950
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1EETs and CYP2J2 inhibit TNF-α-induced apoptosis in pulmonary artery endothelial cells and TGF-β1-induced migration in pulmonary artery smooth muscle cells2013 · 39 citations
  2. 2CYP2J2-derived epoxyeicosatrienoic acids protect against doxorubicin-induced cardiotoxicity by reducing oxidative stress and apoptosis via activation of the AMPK pathway2023 · 5 citations
  3. 3CYP2J2-Derived EETs Attenuated Angiotensin II-Induced Adventitial Remodeling via Reduced Inflammatory Response2016 · 35 citations
  4. 4CYP2J2 Overexpression Protects against Arrhythmia Susceptibility in Cardiac Hypertrophy2013 · 62 citations
  5. 5CYP2J2 metabolites, epoxyeicosatrienoic acids, attenuate Ang II-induced cardiac fibrotic response by targeting Gα12/132017 · 29 citations