Why the study?
Does cilazapril reduce blood pressure more effectively than nitrendipine in elderly hypertensive patients?
Population
114 elderly hypertensive patients, mean age 68 years, with baseline diastolic blood pressure 90-115 mm Hg…
Comparison
Cilazapril 2.5-5 mg once daily for 12 weeks. vs Nitrendipine 10-20 mg once daily for 12 weeks.
Design
RCT, randomized, double-blind
Follow-up
12 weeks
Authors
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Cilazapril may be preferred over nitrendipine for superior trough systolic control in elderly hypertension; extends RCT evidence favoring this ACE inhibitor.
Does cilazapril reduce blood pressure more effectively than nitrendipine in elderly hypertensive patients?
Cilazapril and nitrendipine effectively lower blood pressure in elderly hypertensive patients, with cilazapril offering superior trough systolic blood pressure reduction.
G. Leonetti (1994) studied this question.
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