October 26, 2022European Heart Journal - Cardiovascular ImagingOpen Access

Cardiovascular magnetic resonance phenotyping of heart failure with mildly reduced ejection fraction

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Why the study?

The newly defined HFmrEF category had limited evidence, prompting research into its underlying characteristics, pathophysiology, and cardiac phenotype using multi-parametric CMR.

Population

300 heart failure patients without angina symptoms, history of MI, or coronary intervention

Comparison

HFmrEF vs HFpEF vs HFrEF

Design

Prospective observational study

Authors

LBLouise BrownUniversity of Leeds EIEunice IkongoUniversity of Leeds CSChirstopher E D SaundersonUniversity of Leeds

Discussion

Member takes

Implication

CMR phenotyping feasible in non-ischaemic HFmrEF; leaves open whether features predict outcomes or guide therapy.

Structured PICO

Population

300 patients (final analysis n=273) with a clinical diagnosis of heart failure with no angina symptoms, history of myocardial infarction, or coronary intervention (presumed non-ischaemic), mean age 62.7 ± 13 years, 63% male.

Intervention

Multi-parametric cardiovascular magnetic resonance (CMR) including T1 mapping, extracellular volume (ECV) mapping, late gadolinium enhancement, and measurement of myocardial blood flow at rest and maximal hyperaemia.

Comparator

Comparison between heart failure subtypes: HFmrEF (n=93), HFpEF (n=46), and HFrEF (n=134).

Outcome

Cardiac phenotype defined by CMR parameters (native T1, ECV, myocardial perfusion reserve, diffuse fibrosis, hyperaemic myocardial blood flow, and occult ischaemic heart disease).surrogate

Patients with HFmrEF share most CMR phenotypic characteristics with HFpEF, including microvascular impairment and fibrosis, but have a high prevalence of occult ischaemic heart disease similar to HFrEF.

Cite This Study

Brown et al. (2022) studied this question.

synapsesocial.com/papers/6a8a73ef754a5a619a723f99 https://doi.org/10.1093/ehjci/jeac204

Topics

HFrEF treatment Heart failure Coronary artery disease HFpEF management

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Cardiovascular magnetic resonance phenotyping of heart failure with mildly reduced ejection fraction

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Cardiovascular magnetic resonance phenotyping of heart failure with mildly reduced ejection fraction

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Topics

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