January 1, 1973Cardiovascular Research
Confinement of premature impulses in functional compartments of regions of the A-V conducting system
Population
Preparations of large segments of A-V conducting tissue
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Local refractory gating in AV preparations may underlie reentry; leaves open translation to human arrhythmia substrates.
Structured PICO
P
Population
Preparations of large segments of A-V conducting tissue
I
Intervention
Artificial or natural changes in the refractory period of a single tract of conducting tissue, or ablations of single abnormal tracts
O
Outcome
Functional refractory period of the entire preparationsurrogate
Local refractory periods in the distal A-V conducting system create functional gates, and altering single tracts can modify the entire preparation's refractory period, providing insight into mechanisms of re-entrant arrhythmias.
Cite This Study
Myerburg et al. (1973) studied this question.