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June 1, 1960American Journal of Physiology-Legacy Content

Similarity of cardiovascular responses to exercise and to diencephalic stimulation

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Population

Dogs with closed chests, implanted with devices to measure left ventricular pressure, diameter, and heart rate

Comparison

Diencephalic stimulation vs Exercise on a treadmill

Design

Preclinical

Authors

OSOrville A. SmithAmerican Nurses AssociationRRRobert F. RushmerUniversity of WashingtonELEarl P. LasherNewYork–Presbyterian Hospital

Discussion

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Implication

Diencephalic stimulation elicits exercise-like responses in dogs; leaves open central command mechanisms in human cardiovascular regulation.

Key Points

  • To compare the cardiovascular responses elicited by treadmill exercise with those evoked by localized electrical stimulation in the diencephalon.
  • Surgically implanted instruments to measure left ventricular pressure, ventricular diameter, and heart rate in closed-chest dogs.
  • Trained surviving dogs to exercise on a treadmill to record baseline cardiovascular changes during physical exertion.
  • Stereotaxically placed stimulating electrodes into the diencephalon, applying electrical stimulation either chronically in recovered awake dogs or acutely under chloralose anesthesia.
  • Stimulation of the H1 and H2 fields of Forel and the periventricular gray matter of the third ventricle evoked cardiovascular responses qualitatively similar to those produced by treadmill exercise.

Structured PICO

P
Population
Dogs with closed chests, implanted with devices to measure left ventricular pressure, diameter, and heart rate
I
Intervention
Diencephalic stimulation (H1 and H2 fields of Forel and periventricular gray of the third ventricle)
C
Comparator
Exercise on a treadmill
O
Outcome
Cardiovascular responses (left ventricular pressure, diameter, and heart rate)surrogate

Diencephalic stimulation in dogs produces cardiovascular responses similar to those seen during exercise, suggesting a central neural mechanism for exercise-induced cardiovascular changes.

Cite This Study

Smith et al. (1960) studied this question.

synapsesocial.com/papers/6a8a7809e0083a7c2c437706https://doi.org/10.1152/ajplegacy.1960.198.6.1139
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sympathetic-parasympathetic interaction and accentuated antagonism in conscious dogs1991 · 76 citations
  2. 2Circulatory and Behavioural Effects on Electrical Stimulation of the Sympathetic Vasodilator Areas in the Hypothalamus and the Mesencephalon in Un anesthetized Dogs1967 · 51 citations
  3. 3Changes in Cardiac Rate and Rhythm Produced by Electrical Stimulation of the Brain Stem of Dogs1962 · 11 citations
  4. 4Mapping of ventricular tachycardia induced by thoracic neural stimulation in dogs1986 · 23 citations
  5. 5Left ventricular performance in the conscious dog with chronically denervated heart1972 · 34 citations