September 1, 1983Journal of VirologyOpen Access

Mutations in the major DNA-binding protein gene of herpes simplex virus type 1 result in increased levels of viral gene expression

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Population

Cells infected with herpes simplex virus type 1 (HSV-1)

Comparison

Temperature-sensitive mutations in the HSV-1… vs Wild-type virus infection

Design

Preclinical

Authors

Discussion

Supports HSV-1 major DNA-binding protein as negative regulator of viral gene expression; leaves open in vivo validation and therapeutic implications.

Population

Cells infected with herpes simplex virus type 1 (HSV-1)

Intervention

Temperature-sensitive mutations in the HSV-1 DNA-binding protein gene (at nonpermissive temperature)

Comparator

Wild-type virus infection

Outcome

Viral gene expression (synthesis of viral polypeptides and steady-state level of specific viral transcripts)surrogate

The major DNA-binding protein of HSV-1 acts as a negative regulator of viral gene expression by affecting the abundance of cytoplasmic viral mRNAs.

Godowski et al. (1983) studied this question.

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Supports HSV-1 major DNA-binding protein as negative regulator of viral gene expression; leaves open in vivo validation and therapeutic implications.