Population
Herpes simplex virus 2 temperature-sensitive mutants and infected cells
Comparison
Temperature shift (nonpermissive temperature) vs Wild-type virus and permissive temperature
Design
Preclinical
Authors
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Defective ICP8 nuclear association in HSV-2 mutants may impair replication; leaves open its viability as an antiviral target.
Temperature-sensitive mutations in HSV-2 map to the ICP8 region and affect the nuclear association of the major DNA-binding protein at nonpermissive temperatures.
Spang et al. (1983) studied this question.
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