Stimulation of expression of a herpes simplex virus DNA-binding protein by two viral functions.

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Population

Monkey cells transfected with recombinant plasmids containing herpes simplex virus (HSV) DNA sequences

Comparison

Transfection with recombinant plasmid encoding… vs Transfection with ICP8-encoding plasmids alone

Design

Preclinical

Authors

Discussion

Advances understanding of HSV gene regulation; leaves open validation in disease models and therapeutic targeting.

Population

Monkey cells transfected with recombinant plasmids containing herpes simplex virus (HSV) DNA sequences

Intervention

Transfection with recombinant plasmid encoding the HSV alpha (immediate-early) ICP4 and ICP0 genes along with the ICP8 gene

Comparator

Transfection with ICP8-encoding plasmids alone

Outcome

Expression and localization of the major HSV DNA-binding protein ICP8surrogate

Two separate viral functions (mapping near ICP4 and ICP0) can synergistically activate herpesvirus early gene expression (ICP8) in transfected cells.

Quinlan et al. (1985) studied this question.

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