May 1, 1992Journal of VirologyOpen Access

Herpes simplex viruses with mutations in the gene encoding ICP0 are defective in gene expression

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Population

Vero and HeLa cells

Comparison

Herpes simplex virus type 1 mutants with codon… vs Wild-type HSV-1 virus

Design

Preclinical

Authors

Discussion

Defective ICP0 impairs viral replication in animal models; leaves open whether targeting ICP0 could limit human infections.

Population

Vero and HeLa cells

Intervention

Herpes simplex virus type 1 (HSV-1) mutants with codon insertions and deletions in IE-0 (gene encoding ICP0)

Comparator

Wild-type HSV-1 virus

Outcome

Virus yield, plaque efficiency, and steady-state levels of RNAsurrogate

ICP0 is not essential for virus growth in tissue culture, but defects in this gene impair virus replication and delay gene expression.

Chen et al. (1992) studied this question.

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