October 8, 2010American Journal of HypertensionOpen Access

The Ouabain-Binding Site of the 2 Isoform of Na,K-ATPase Plays a Role in Blood Pressure Regulation During Pregnancy

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Structured PICO

Population

Gene-modified α2(R/R) mice (ouabain-resistant) and wild-type α2(S/S) mice (ouabain-sensitive) before and during pregnancy

Intervention

Genetic modification resulting in ouabain-resistant α2(R/R) Na,K-ATPase

Comparator

Wild-type α2(S/S) mice (ouabain-sensitive)

Outcome

Systolic blood pressure (SBP) before and during pregnancysurrogate

The cardiotonic steroid-binding site of the α2 Na,K-ATPase is involved in maintaining normal systolic blood pressure during pregnancy in a mouse model.

Discussion

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Implication

Supports α2 Na,K-ATPase site in mouse gestational BP control; hypothesis-generating, human relevance untested.

Cite This Study

Oshiro et al. (2010) studied this question.

synapsesocial.com/papers/6a8a7aa31acf8e321fbd80b5 https://doi.org/10.1038/ajh.2010.195

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The Ouabain-Binding Site of the 2 Isoform of Na,K-ATPase Plays a Role in Blood Pressure Regulation During Pregnancy

Structured PICO

Discussion

Implication

Cite This Study

The Ouabain-Binding Site of the 2 Isoform of Na,K-ATPase Plays a Role in Blood Pressure Regulation During Pregnancy

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider