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March 1, 1992Clinical and Experimental Pharmacology and Physiology

Cardiovascular Habituation to Emotional Stress in Lyon Hypertensive Rats

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Population

Freely moving genetically hypertensive, normotensive and low blood pressure rats of the Lyon strain

Comparison

Stress period vs Control period (animals left undisturbed for 11 h)

Design

Preclinical

Follow-up

22 hours (two 11-hour periods)

Authors

JCJulien ClaudeCentre National de la Recherche ScientifiqueJSJoëlle SacquetUniversité Claude Bernard Lyon 1PKP. KandzaCentre National de la Recherche Scientifique

Discussion

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Implication

Suggests stress habituation in hypertensive rat models; leaves open translation to human cardiovascular responses.

Structured PICO

P
Population
Freely moving genetically hypertensive (LH), normotensive (LN) and low blood pressure (LL) rats of the Lyon strain
I
Intervention
Stress period (jet of air applied for 20 min every hour during an 11 h period)
C
Comparator
Control period (animals left undisturbed for 11 h)
O
Outcome
Intra-aortic blood pressure and heart ratesurrogate

Lyon hypertensive rats demonstrate cardiovascular habituation and blunted sympathoadrenal activation to repeated emotional stress.

Cite This Study

Claude et al. (1992) studied this question.

synapsesocial.com/papers/6a8a7b665246293882fd9089https://doi.org/10.1111/j.1440-1681.1992.tb00437.x

Topics

Hypertension management
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Also Consider

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