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March 1, 1989Journal of Hypertension

Selective central alpha-2 adrenoceptor control of regional haemodynamic responses to air jet stress in conscious spontaneously hypertensive rats

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Why the study?

Does central administration of guanabenz alter regional hemodynamic responses to air jet stress in spontaneously hypertensive rats?

Population

Conscious chronically instrumented spontaneously hypertensive rats (SHR)

Comparison

Intracerebroventricular administration of the… vs Intracerebroventricular administration of…

Design

Preclinical

Authors

DKDaniel R. KapustaLouisiana State University Health Sciences Center New OrleansSKStein KnardahlNational Institute of Occupational HealthJKJ P KoepkeNorthside Hospital

Discussion

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Implication

Hypothesis-generating for bed-specific central α2 control of stress sympathoexcitation in SHR; leaves open translation to human hypertension.

Structured PICO

Does central administration of guanabenz alter regional hemodynamic responses to air jet stress in spontaneously hypertensive rats?

P
Population
Conscious chronically instrumented spontaneously hypertensive rats (SHR)
I
Intervention
Intracerebroventricular (i.c.v.) administration of the alpha 2-adrenoceptor agonist guanabenz in cumulative doses of 5 and 25 micrograms
C
Comparator
Intracerebroventricular (i.c.v.) administration of isotonic saline vehicle
O
Outcome
Mean arterial pressure (MAP), heart rate, and regional vascular resistance (renal, mesenteric, hindquarters) responses to air jet stresssurrogate

Central alpha 2-adrenoceptors independently control environmental stress-stimulated sympathetic neural outflow to different vascular beds in spontaneously hypertensive rats.

Cite This Study

Kapusta et al. (1989) studied this question.

synapsesocial.com/papers/6a71038b75498292b70a7feahttps://doi.org/10.1097/00004872-198903000-00004

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Central beta-adrenergic receptors mediate renal nerve activity during stress in conscious spontaneously hypertensive rats.1985 · 60 citations
  2. 2Role of angiotensin II and catecholamines in blood pressure variability responses to stress in SHR1996 · 27 citations
  3. 3Beta-2 Adrenoceptor Mediated Vasodilation: Role in Cardiovascular Responses to Acute Stressors in Spontaneously Hypertensive Rats1991 · 11 citations
  4. 4Acute stress increases venomotor tone in conscious rats1996 · 19 citations
  5. 5ROLE OF BAROREFLEX AND CENTRAL α2‐ADRENERGIC RECEPTOR SYSTEMS IN THE DIURNAL VARIATION OF BLOOD PRESSURE AND HEART RATE IN NORMOTENSIVE AND HYPERTENSIVE RATS1995 · 1 citations