Key result
Acute psychological stress via air-jet increased mean circulatory filling pressure by 0.95 +/- 0.09 mmHg, indicating venoconstriction mediated primarily via the alpha 2-receptor subtype.
Why the study?
Does acute psychological stress cause venoconstriction in conscious rats, and which receptor subtypes mediate this response?
Population
Conscious male Sprague-Dawley rats instrumented with indwelling catheters in a femoral artery and vein and a…
Comparison
Air-jet stress before and after treatment with… vs Saline treatment and baseline pre-treatment…
Design
Preclinical
Authors
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Hypothesis-generating for alpha-2 mediated venoconstriction in stress; leaves open translation to human cardiovascular responses.
Does acute psychological stress cause venoconstriction in conscious rats, and which receptor subtypes mediate this response?
Acute psychological stress induces venoconstriction in conscious rats, a response that appears to be mediated primarily via the alpha 2-adrenergic receptor subtype.
Martin et al. (1996) studied Acute psychological stress. Air-jet stress vs. Baseline was evaluated on Mean arterial pressure (MAP), heart rate (HR), and mean circulatory filling pressure (MCFP). Acute psychological stress via air-jet increased mean circulatory filling pressure by 0.95 +/- 0.09 mmHg, indicating venoconstriction mediated primarily via the alpha 2-receptor subtype.
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