May 1, 1985Hypertension

Central beta-adrenergic receptors mediate renal nerve activity during stress in conscious spontaneously hypertensive rats.

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Population

Conscious spontaneously hypertensive rats (SHR)

Comparison

Intracerebroventricular administration of… vs i.c.v. saline vehicle, and intravenous…

Design

Preclinical

Authors

JKJ P KoepkeNorthside Hospital GDGerald F. DiBonaGeneral Cardiology

Discussion

Member takes

Implication

Central beta-adrenergic mediation of stress-induced renal changes in hypertension; leaves open clinical translation in humans.

Structured PICO

Population

Conscious spontaneously hypertensive rats (SHR)

Intervention

Intracerebroventricular (i.c.v.) administration of beta-adrenergic receptor antagonists (d,l-propranolol or timolol, 30 micrograms in 2 microL of isotonic saline) prior to stressful environmental stimulation (air jet to head)

Comparator

i.c.v. saline vehicle, and intravenous administration of the same doses of d,l-propranolol or timolol

Outcome

Renal sympathetic nerve activity and urinary sodium excretion (UNaV) responses to stressful environmental stimulationsurrogate

Central nervous system beta-adrenergic receptors mediate the increased renal sympathetic nerve activity and decreased urinary sodium excretion responses to environmental stress in spontaneously hypertensive rats.

Cite This Study

Koepke et al. (1985) studied this question.

synapsesocial.com/papers/6a71038b75498292b70a7fee https://doi.org/10.1161/01.hyp.7.3.350

View Full Paper

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Bookmark

Central beta-adrenergic receptors mediate renal nerve activity during stress in conscious spontaneously hypertensive rats.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Central beta-adrenergic receptors mediate renal nerve activity during stress in conscious spontaneously hypertensive rats.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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