Distinct abdominal and gluteal adipose tissue transcriptome signatures are altered by exercise training in African women with obesity

Figures

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  Figure 1. Comparison of abdominal SAT vs gluteal SAT, before (A) and after (B) exercise training respectively. Blue: Higher gene expression in aSAT (LFC < −0.58. Red: Lower gene expression in aSAT (LFC > 0.58), Orange: p-value < 0.001. The horizontal line corresponds to p < 0.001 and the vertical lines mark a |LFC | > 0.58. (A) aSAT vs gSAT at baseline. (B) aSAT vs gSAT after exercise training. (C) Overlap of genes with changed expression (|LFC | > 0.58) between gSAT and aSAT. PRE: difference between aSAT and gSAT pre-exercise training (at baseline); PT: difference between aSAT and gSAT post-exercise training.

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  Figure 2. GO term enrichment of differentially expressed genes between gluteal and abdominal SAT at baseline.

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  Figure 3. Comparison of gene expression changes induced by exercise training in gSAT (A) and aSAT (B), respectively. The volcano plots highlight genes with p-value < 0.001 and log2 fold change |LFC | > 0.58. Red: gene expression upregulated after exercise training (LFC > 0.58), Blue: gene expression downregulated after exercise training (LFC < −0.58). Orange: p-value < 0.001. The horizontal line corresponds to p < 0.001 and the vertical lines mark a | LFC | > 0.58. (A) Gene expression changes in gSAT after exercise. (B) Gene expression changes in aSAT after exercise training. (C) Overlapping genes with changed expression (|LFC| > 0.58) in both depots before and after exercise training.

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  Figure 4. GO-term Enrichment of differentially expressed genes in gluteal SAT after exercise training.

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  Figure 5. GO-term Enrichment of differentially expressed genes in abdominal SAT after exercise training.