Why the study?
Citalopram exhibits the greatest cardiotoxic effect among SSRIs, causing long QT syndrome and ventricular arrhythmias, prompting evaluation of nicorandil's protective effects against this cardiotoxicity.
Does nicorandil prevent QT prolongation and myocardial damage caused by citalopram in male rats?
Population
Male rats
Comparison
Nicorandil vs normal saline vs 5-HD vs 5-HD + nicorandil (all with citalopram) vs untreated control
Design
Randomized animal study
Authors
Loading...
Nicorandil failed to prevent citalopram-induced QT prolongation in rats yet reduced myocardial damage; leaves open any protective role for mito-KATP opening in humans.
Does nicorandil prevent QT prolongation and myocardial damage caused by citalopram in male rats?
In a rat model, nicorandil reduced citalopram-induced myocardial histologic damage and apoptosis but failed to prevent QT prolongation.
Aktürk et al. (2023) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: