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May 1, 1985British Journal of PharmacologyOpen Access

Comparison of negative inotropic potency, reversibility, and effects on calcium influx of six calcium channel antagonists in cultured myocardial cells

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Population

Cultured chick embryo ventricular cells

Comparison

Six calcium channel antagonists (verapamil… vs Compared against each other

Design

Preclinical

Authors

WBWilliam H. BarryBibliothèque Nationale de FranceJHJohn D. HorowitzGeneral CardiologyTSThomas W. SmithBoston University

Discussion

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Implication

Nonuniform calcium antagonist effects on inotropy in chick cells warrant caution extrapolating to patients; leaves open mechanism uniformity in human myocardium.

Structured PICO

P
Population
Cultured chick embryo ventricular cells
I
Intervention
Six calcium channel antagonists (verapamil, methoxyverapamil (D600), nifedipine, lidoflazine, perhexiline and diltiazem)
C
Comparator
Compared against each other
O
Outcome
Negative inotropic potency (50% inhibition of contractile amplitude), reversibility (time required for recovery of contractility), and effects on calcium influx (45Ca uptake)surrogate

In cultured chick embryo ventricular cells, the relationship between the degree of inhibition of calcium influx and negative inotropic effects is not uniform for all calcium channel antagonists.

Cite This Study

Barry et al. (1985) studied this question.

synapsesocial.com/papers/6a8a824981f71cbdf7de85e0https://doi.org/10.1111/j.1476-5381.1985.tb08830.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Multiple effects of calcium antagonists on plateau currents in cardiac Purkinje fibers.1975 · 316 citations
  2. 2Verapamil kinetics in normal subjects and patients with coronary artery spasm1981 · 113 citations
  3. 3Calcium Channel Blocking Agents in the Treatment of Cardiovascular Disorders. Part I: Basic and Clinical Electrophysiologic Effects1980 · 331 citations
  4. 4Mechanisms of transmembrane calcium movement in cultured chick embryo ventricular cells1982 · 131 citations
  5. 5PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT1951 · 318,705 citations