Why the study?
What are the negative inotropic properties of different calcium antagonists in diseased human myocardial tissue?
Population
Electrically driven human papillary muscle strips and human auricular trabeculae obtained during cardiac…
Comparison
Calcium antagonists applied in cumulative… vs Control and comparison between different calcium…
Design
Preclinical
Authors
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May inform calcium antagonist choice in low-EF patients; leaves open translation from animal tissue to human myocardium.
What are the negative inotropic properties of different calcium antagonists in diseased human myocardial tissue?
Calcium antagonists exhibit significant and varying degrees of negative inotropic effects in diseased human myocardial tissue, with verapamil showing the greatest potential negative inotropism relative to therapeutic plasma concentrations.
Schwinger et al. (1990) studied this question.
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