June 1, 2001RNAOpen Access

The 3′-end-processing factor CPSF is required for the splicing of single-intron pre-mRNAs in vivo

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Population

In vivo model studying pre-mRNA splicing

Design

Preclinical

Authors

Discussion

Animal data link CPSF inhibition to defective single-intron splicing; leaves open validation and therapeutic targeting in mammalian systems.

Population

In vivo model studying pre-mRNA splicing

Intervention

Influenza virus NS1A protein effector domain

Outcome

Inhibition of 3'-end formation and splicing of single-intron pre-mRNAs

The 3'-end-processing factor CPSF is required for the splicing of single-intron pre-mRNAs in vivo.

Li et al. (2001) studied this question.

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Animal data link CPSF inhibition to defective single-intron splicing; leaves open validation and therapeutic targeting in mammalian systems.