Parechovirus A Pathogenesis and the Enigma of Genotype A-3

Figures

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  Figure 1. (a) Twofold axis of symmetry of PeV-A3 (Parechovirus A) at 4.3 Å resolution, canyon indicated by the arrow, (b) representative fit of the VP0 atomic model, and (c) capsid model showing positions of VP0 (yellow), VP1 (red), and VP3 (green). In blue are the symmetry axes—fivefold pentagon, threefold triangle, and twofold ellipse. Image used under the terms of the Creative Commons Attribution License (CC BY 4.0.) from Shakeel, S. et al., 2016 [6].

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  Figure 2. Immunofluorescence image of human airway epithelia (HAE) inserts infected with PeV-A1 and PeV-A3. Both genotypes appear to have a tropism for basal cells in the airway epithelium. Legend: Blue—DAPI (nuclei), Red—β-tub (ciliated cells), Green—PeV-A, and purple—p63 (basal cells). Image used under the terms of the Creative Commons Attribution License (CC BY 4.0.) from Karelehto E. et al., 2018 [83].