September 1, 1997Endocrinology

Human Pregnancy Serum Contains at Least Two Distinct Proteolytic Activities with the Ability To Degrade Insulin-Like Growth Factor Binding Protein-31

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Population

Pregnant human serum (PHS) and nonpregnant human serum (NHS)

Comparison

Biochemical purification and characterization vs Nonpregnant human serum and untreated serum…

Design

Preclinical

Authors

Discussion

Reveals pregnancy-specific IGFBP-3 protease activity; leaves open its role in gestational IGF dynamics and clinical relevance.

Population

Pregnant human serum (PHS) and nonpregnant human serum (NHS)

Intervention

Biochemical purification and characterization (size-exclusion chromatography, addition of plasminogen activators and protease inhibitors)

Comparator

Nonpregnant human serum (NHS) and untreated serum fractions

Outcome

Proteolytic degradation of 125I-IGFBP-3surrogate

Pregnant human serum contains a unique >150-kDa protease activity capable of degrading IGFBP-3 that is not present in nonpregnant serum.

Bang et al. (1997) studied this question.

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