What question did this study set out to answer?

To investigate the influence of age on arterial antioxidant enzyme activity and the progression of atherogenesis in intracranial versus extracranial arteries among males lacking classic risk factors.

November 1, 2001StrokeOpen Access

Age-Related Effects on Atherogenesis and Scavenger Enzymes of Intracranial and Extracranial Arteries in Men Without Classic Risk Factors for Atherosclerosis Editorial Comment

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Authors

FDFrancesco Paolo D’ArmientoUniversity of Siena ABAntonio BianchiUniversità Cattolica del Sacro Cuore FNFilomena de NigrisUniversity of Campania "Luigi Vanvitelli"

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Implication

Observational study reveals delayed atherogenesis in male intracranial versus extracranial arteries, indicating higher baseline antioxidant protection that wanes with advancing age.

Key Points

To investigate the influence of age on arterial antioxidant enzyme activity and the progression of atherogenesis in intracranial versus extracranial arteries among males lacking classic risk factors.
Examined arterial tissue across four age cohorts without classic cardiovascular risk factors: 48 premature fetuses (6.4±0.8 months), 58 children (7.9±3.8 years), 42 adults (42.5±5.1 years), and 40 elderly individuals (71.8±3.4 years; all male).
Quantified atherosclerotic lesions via computer-assisted imaging in intracranial (middle cerebral, basilar) and extracranial (coronary, carotid, abdominal aorta) arteries.
Assessed tissue levels of macrophages, apolipoprotein B, oxidized LDL, and matrix metalloproteinase-9 using immunocytochemistry alongside measuring wall activity of 4 antioxidant enzymes.
Atherosclerosis severity was 6- to 19-fold greater in extracranial than in intracranial arteries (P<0.01) and increased linearly across age groups.
Intracranial arteries demonstrated significantly higher antioxidant enzyme activities compared to extracranial vessels, but this antioxidant protection dropped sharply at older ages in parallel with accelerated intracranial atherogenesis and elevated matrix metalloproteinase-9 expression.

Cite This Study

D’Armiento et al. (2001) studied this question.

synapsesocial.com/papers/6a8a89d56fc170cbc2fbf8b1 https://doi.org/10.1161/hs1101.098520

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Implication

Observational study reveals delayed atherogenesis in male intracranial versus extracranial arteries, indicating higher baseline antioxidant protection that wanes with advancing age.

Age-Related Effects on Atherogenesis and Scavenger Enzymes of Intracranial and Extracranial Arteries in Men Without Classic Risk Factors for Atherosclerosis Editorial Comment

Discussion

Member takes

Implication

Key Points

Cite This Study

Age-Related Effects on Atherogenesis and Scavenger Enzymes of Intracranial and Extracranial Arteries in Men Without Classic Risk Factors for Atherosclerosis Editorial Comment

Discussion

Member takes

Implication

Key Points

Cite This Study

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