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February 1, 1997AJP Heart and Circulatory Physiology

Relationship between "extension of refractoriness" and probability of successful defibrillation

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Why the study?

Does shock-induced extension of refractoriness correlate with successful defibrillation in isolated rabbit hearts?

Population

5 isolated rabbit hearts undergoing 111 fibrillation episodes

Comparison

Defibrillation attempted by 8-ms pulses… vs Unsuccessful defibrillation shocks

Design

Preclinical

Authors

OTO.H. TovarBielefeld UniversityJJJanice L. JonesUniversity of North Carolina at Chapel Hill

Discussion

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Overview

Supports refractoriness extension hypothesis in rabbit hearts; leaves open translation to clinical defibrillation.

Structured PICO

Does shock-induced extension of refractoriness correlate with successful defibrillation in isolated rabbit hearts?

P
Population
5 isolated rabbit hearts undergoing 111 fibrillation episodes
I
Intervention
Defibrillation attempted by 8-ms pulses (65% tilt) delivered through epicardial patches
C
Comparator
Unsuccessful defibrillation shocks
O
Outcome
Postshock response duration (from shock to repolarization)surrogate

Shock-induced response duration correlates with successful defibrillation, supporting the extension of refractoriness hypothesis.

Cite This Study

Tovar et al. (1997) studied this question.

synapsesocial.com/papers/6a8a97b40e1a8f7244fd8573https://doi.org/10.1152/ajpheart.1997.272.2.h1011
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Electrophysiology of ventricular fibrillation and defibrillation2000 · 21 citations
  2. 2Prediction of Defibrillation Outcome by Epicardial Activation Patterns Following Shocks Near the Defibrillation Threshold2000 · 40 citations
  3. 3Heart defibrillation: relationship between pacing threshold and defibrillation probability2019 · 7 citations
  4. 4Effect of duration of ventricular fibrillation on defibrillation efficacy in humans.1990 · 94 citations
  5. 5Early Recurrence of Ventricular Fibrillation After Successful Defibrillation During Prolonged Global Ischemia in Isolated Rabbit Hearts2007 · 15 citations